Ø Teachers: Daniel
Kling (daniel.kling@rmv.se)
and Andreas Tillmar (andreas.tillmar@rmv.se)
Brief description
The aim of this workshop is to give a comprehensive introduction to X-chromosomal markers in forensic
genetics with a focus on kinship applications. The workshop is divided into
three session, i) Basic where we introduce concepts
such as the likelihood ratio principle and how underlying theory for
calculations, ii) Advanced where we continue with concepts such as linkage and
linkage disequilibrium and iii) Applications and examples where we showcase
interesting cases. Theoretical presentations will be mixed with hands-on
exercises.
Statistical
methods are introduced and the freely available software FamLinkX
is exemplified. The open software R is introduced, and the relevance for
plotting of pedigrees and estimation of haplotype frequencies is demonstrated.
Lectures
will be in English.
Preparation
Participants should bring their own laptop if possible.
Users are encouraged to download and install the biostatistical software
R, any version, as well as FamLinkX (version 2.9.3) which may be used in exercises.
General information
Workshop
Time & Date: 16:00-19:00 (CET), March 10, 17 and 24, 2025
Preliminary schedule (subject to changes)
Session
1 – Basics (March 10)
16:00 Introduction
16:15-17:00 Basics
of kinship testing and the utility of X-chromosomal markers
17:00-17:10 Short break
17:10-18:00 Software: FamLinkX
18:05-18:40 Theory and hands-on: Exercises
and Solutions
FamLinkX:
Exercises
and Solutions
and Files
18:40-19:00 Summary
Session
2 – Advanced (March 17)
16:00 Introduction (Question and
Answers)
16:15-17:00 Advanced theory
17:00-17:10 Short break
17:10-18:00 Haplotypes
and databases
18:05-18:40 Exercises (see Session 1 links)
18:40-19:00 Summary
Session
3 – Applications and examples (March 24)
16:00 Introduction
16:15-17:00 Summary of
theory and some more advanced topics
17:00-17:10 Short break
17:10-18:00 Case
examples and more advanced topics
18:05-18:40 Exercises (see Session 1 links)
18:40-19:00 Summary