NORBIS course Jan 6-10 2020: Statistical methods in relatedness and pedigree analysis

Teachers: Magnus Dehli Vigeland and Thore Egeland

Practicalities

The course is arranged by NORBIS, a Norwegian research school in bioinformatics, biostatistics and systems biology. The program on the NORBIS home page is slightly revised below.
Preparations: All participants must bring a laptop with the R software installed. We also highly recommend the Rstudio desktop version. For pedigree analysis in R we will use the ped suite, in particular the packages pedtools, pedprobr, ribd, and forrel.
Location: Room 1151 in the Domus Medica building.
Exam: The take home exam problems have been emailed to the participants. Data for the exam problems: snp_data_exam.ped, GM.fam.

• 09-11 Introduction I: Pedigrees, genetics and probabilities.
• 11-12 Exercises I.
• 12-13 Lunch.
• 13-15 Introduction II: Pedigree analysis in R with the ped suite.
• 15-16:30 Exercises II.

• 09-11 Relatedness I: IBD and coefficients of relatedness and R.
• 11-12 Exercises III.
• 12-13 Lunch.
• 13-15 Relatedness II: Why some siblings are more equal than others.
• 15-16:30 Exercises III continued.

• 09-11 Recombination and genetic linkage.
• 11-12 Exercises IV.
• 12-13 Lunch.
• 13-15 Linkage analysis in medical genetics
• 15-16:30 Exercises IV continued.

• 09-11 Inference of relatedness and pedigree reconstruction and R.
• 11-12 Exercises V. Data for exercises: reconstruction1.ped, AustraliaData.ped, AustraliaFreqs.rds.
• 12-13 Lunch.
• 13-15 Forensics I: Paternity cases, complex identification cases. Mutations.
• 15-16:30 Exercises VI (Exercises 1-4)

• 09-11 Forensics II: Further interpretation of the likelihood ratio and exclusion power
• 11-12 Exercises VI continued (Exercises 5-9).
• 12-13 Lunch.
• 13-16:30 Case study: The missing grandchildren of Argentina. Exercises (finish previous). Summary.

Updated Jan 19 2020. You may send comments to thore.egeland@gmail.com