Program Workshop: Familial Testing and Identification
Date and venue: March 15-17 2017, Nicosia, Cyprus
Teachers: Thore Egeland, Yarimar Ruiz, Lourdes Prieto
Course organiser: Yarimar Ruiz
Version: March 13 2017, Thore Egeland
Preparations for the workshop and the exercises:
Participants should bring a laptop with the freely available software
Familias 3 installed.
In addition, the free R software will be introduced and used for plotting and participants should download . Assistance for installation will be provided at the workshop, if needed. Note that installation is typically only possible if you are administrator on your laptop. The exercises are from the book
Relationship Inference with Familias and R
by Egeland, Kling, and Mostad, but the required material (exercises, solutions, input files) are freely available. Please download the following files to your computer or a memory stick as they will be needed for the exercises:
solutions all exercises,
input files Familias exercises
Wednesday March 15
Thursday March 16
Friday March 17
- 08.30 − 08.45 Practical information. Yarimar Ruiz
- 08.45 − 09.45 Population genetics concepts of interest.
- 09.45 − 10.15 Coffee break.
- 10.15 − 11.30 Role of DNA databases in the identification of victims and missing persons:
Population and forensic databases, choosing the software (technical and legal criteria),
direct and indirect matches, false positives (incomplete pedigrees, partial profiles),
false negatives (non-paternity, mutation), international comparisons.
11.30 − 12.30 Basics: Paternity and kinship analysis:
methods and principles. Paternity Index, Likelihood Ratio,
W, Bayes theorem. Statistical evaluation of DNA evidence in DVI scenarios: concepts.
- 12.30 − 13.45 Lunch.
- 13.45 − 14.15 Basics.
Introduction to Familias. Thore Egeland
- 14.15 − 15.00 Familias
- 15.00 − 15.30 Import from GeneMapper.
Plotting pedigrees in R. Demo,
- 08.00 − 09.00 Familias
Exercises: 3.1-3.2. Extra exercises.
- 09.00 − 09.45 DVI continued. Familial searching . Thore Egeland
- 09.45 − 10.15 Coffee break
- 10.15 − 12.30
Exercises: 3.3 and previously unfinished exercises. Cases from participants.
- 12.30 − 13.45 Lunch
- 13.45 − 15.30 GHEP-ISFG collaborative simulated exercise for DVI/MPI:
Lessons learned about large scale profile database comparisons.
Supp data from the paper: Vullo C et al., Forensic Sci Int: Genet 21: 45-53 (2015).